Synthesis of Benzofuro[6,7-<i>d</i>]thiazoles, Benzofuro[7,6-<i>d</i>]thiazoles and 6-Arylaminobenzo[<i>d</i>]thiazole-4,7-diones as Antifungal Agent

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  • Ryu Chung-Kyu
    College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
  • Nho Ji-Hee
    College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
  • Jin Guohua
    College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
  • Oh Sun Young
    College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
  • Choi Soo Jung
    College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University

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  • Synthesis of Benzofuro[6,7-d]thiazoles, Benzofuro[7,6-d]thiazoles and 6-Arylaminobenzo[d]thiazole-4,7-diones as Antifungal Agent

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Abstract

Benzofuro[6,7-d]thiazoles, benzofuro[7,6-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species and Cryptococcus neoformans. Among them tested, many of synthesized compounds showed potent antifungal activity. The compounds 4d, 6e and 6h completely inhibited the growth of all Candida and Aspergillus species tested at the MIC level of 6.3 µg/mL. The results suggest that benzofuro[6,7-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones would be promising antifungal agents.

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