Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation : 6- and 12-Month Follow-up by Optical Coherence Tomography

• Konishi Akihide

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Shinke Toshiro

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Otake Hiromasa

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Takaya Tomofumi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Nakagawa Masayuki

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Inoue Takumi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Hariki Hirotoshi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Osue Tsuyoshi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Taniguchi Yu

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Iwasaki Masamichi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Nishio Ryo

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Hiranuma Noritoshi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Kinutani Hiroto

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Kuroda Masaru

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Takahashi Hachidai

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Terashita Daisuke

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Shite Junya

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

• Hirata Ken-ichi

  Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine

書誌事項

タイトル別名

• Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation
• – 6- and 12-Month Follow-up by Optical Coherence Tomography –

抄録

Background:Nobori is a novel biolimus A9-eluting stent (BES) coated with a biodegradable polymer only on the abluminal side, which degrades over 6–9 months post-stent deployment. The course of vessel reaction after deployment at these time points remains unclear.Methods and Results:We serially evaluated 28 BES implanted in de novo coronary lesions of 23 patients using optical coherence tomography (OCT) at 6 and 12 months post-stenting. Standard OCT variables, the percentage of stent with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (72±23 to 82±25 µm, P=0.006) from the 6- to the 12-month follow-up, without a significant decrease in minimum lumen area (P=0.30). The incidences of uncovered and malapposed struts were low at 6 months and reduced further at 12 months (3.96±3.97% to 1.51±1.63%, P=0.001, and 0.50±1.84% to 0.06±0.24%, P=0.20, respectively). The frequency of stent with PLIA decreased during the follow-up (57% to 32%, P=0.05) and that with in-stent thrombi also numerically decreased (7% to 0%, P=0.24).Conclusions:Neointimal hyperplasia was persistently suppressed following BES implantation up to 12 months. Simultaneously, favorable vessel healing was achieved at 6 months without a delaying adverse reaction for up to 12 months. (Circ J 2014; 78: 1882–1890)

収録刊行物

• Circulation Journal

  Circulation Journal 78 (8), 1882-1890, 2014

  一般社団法人 日本循環器学会

キーワード

• Biolimus A9-eluting stent
• Mid-term vessel healing
• Optical coherence tomography

詳細情報

• CRID: 1390001205107582208
• NII論文ID: 40020130189
• NII論文ID: 130004427944
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-13-1474
• COI: 1:STN:280:DC%2BC2cfgtlCltg%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 025599266
• PubMed: 24909891
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025599266
• Web Site: https://www.jstage.jst.go.jp/article/circj/78/8/78_CJ-13-1474/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015175998
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可