Connection between periodontitis and Alzheimer׳s disease: possible roles of microglia and leptomeningeal cells
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- Wu Zhou
- Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Japan
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- Nakanishi Hiroshi
- Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Japan
書誌事項
- タイトル別名
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- Connection Between Periodontitis and Alzheimer’s Disease: Possible Roles of Microglia and Leptomeningeal Cells
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抄録
Neuroinflammation, inflammation of the brain, is strongly implicated in Alzheimer’s disease (AD), which can be enhanced by systemic inflammation. Therefore, the initiation and progression of AD are affected by systemic diseases such as cardiovascular disease and diabetes. This concept suggests a possible link between periodontitis and AD because periodontitis is a peripheral, chronic infection that elicits a significant systemic inflammatory response. There is now growing clinical evidence that chronic periodontitis is closely linked to the initiation and progression of AD. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to the brain-resident microglia, which in turn initiate neuroinflammation. Furthermore, it is apparent that senescent-type microglia respond in an exaggerated manner to systemic inflammation. It is estimated that a high percentage of adults are suffering from periodontitis, and the prevalence of periodontitis increases with age. Therefore, chronic periodontitis can be a significant source of covert systemic inflammation within the general population. The present review article highlights our current understanding of the link between periodontitis and AD.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 126 (1), 8-13, 2014
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155489920
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- NII論文ID
- 130004684880
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXhs1OgsL%2FL
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025790478
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- PubMed
- 25168594
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可