Vascular Toxicity of Phosphate in Chronic Kidney Disease : Beyond Vascular Calcification

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  • Gross Priscilla
    INSERM Unit 1088, Jules Verne University of Picardie
  • Six Isabelle
    INSERM Unit 1088, Jules Verne University of Picardie
  • Kamel Said
    INSERM Unit 1088, Jules Verne University of Picardie Amiens University Medical Center
  • Massy Ziad A.
    INSERM Unit 1088, Jules Verne University of Picardie Division of Nephrology, Ambroise Paré Hospital and Paris-Ile-de-France-Ouest University

書誌事項

タイトル別名
  • Vascular Toxicity of Phosphate in Chronic Kidney Disease
  • – Beyond Vascular Calcification –

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抄録

Chronic kidney disease (CKD) is characterized by high cardiovascular morbidity/mortality, which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED). Hyperphosphatemia, a feature of CKD, is a well-known inducer of VC in preclinical models and is associated with poor outcomes in epidemiological studies. However, it remains to be seen whether lowering phosphate levels in CKD patients reduces VC and the morbidity/mortality rate. Furthermore, it is now clear from preclinical and clinical studies that phosphate is involved in ED. The present article reviews the direct and indirect mechanisms (eg, via fibroblast growth factor 23 and/or parathyroid hormone) by which hyperphosphatemia influence the onset of VC and ED in CKD. (Circ J 2014; 78: 2339–2346)

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (10), 2339-2346, 2014

    一般社団法人 日本循環器学会

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