Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies

• Hatakeyama Susumi

  Graduate School of Biomedical Sciences, Nagasaki University, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan

抄録

Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita–Baylis–Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C–H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 62 (11), 1045-1061, 2014

  公益社団法人 日本薬学会

キーワード

• total synthesis
• natural product
• asymmetric synthesis
• heterocycle synthesis

詳細情報

• CRID: 1390282679155139584
• NII論文ID: 130004712908
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c14-00474
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 025880428
• PubMed: 25366310
• Web Site: http://id.ndl.go.jp/bib/025880428
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025880428
• Web Site: https://www.jstage.jst.go.jp/article/cpb/62/11/62_c14-00474/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015229737
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可