Renin Inhibition Improves Ovariectomy-Induced Osteoporosis of Lumbar Vertebra in Mice
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- Zhang Fang-Yi
- Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology
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- Yang Feng-Jian
- Department of Orthopaedics, Huadong Hospital, Fudan University
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- Yang Jiu-Lin
- Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology
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- Wang Liang
- Department of Orthopaedics, The 309th Hospital of Chinese People's Liberation Army
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- Zhang Yan
- Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology
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The skeletal renin–angiotensin system (RAS) is involved in the progression of osteoporosis and the active peptide within the RAS, angiotensin II (ANG II), has deleterious effects on bones. This study was performed to investigate whether suppression of the rate-limiting step of the RAS cascade by the renin inhibitor aliskiren has a benefit on trabecular bone in osteoporotic mice. A postmenopausal osteoporosis model was induced by bilateral ovariectomy. The ovariectomized (OVX) mice were treated with a low (5 mg/kg) or high (25 mg/kg) dose of aliskiren for 6 weeks. Micro-computed tomography was performed to detect trabecular bone parameters of lumbar vertebra and to obtain 3-dimensional (3D) images. Treatment with aliskiren markedly increased bone volume over total volume (p<0.05), trabecular bone number (p<0.05), connectivity density (p<0.05), and bone mineral density (p<0.05) and reduced trabecular bone separation (p<0.05) compared to vehicle-treated OVX mice. Similarly, the 3D images were consistent with the quantitative data that showed aliskiren could markedly reverse the ovariectomy-induced pathological changes of trabecular bone. Thus, this study indicated that the treatment of estrogen-deficient mice with aliskiren could markedly increase bone mass and improve trabecular bone structure, suggesting its potential application in treating postmenopausal osteoporosis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (12), 1994-1997, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632409728
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- NII論文ID
- 130004693804
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025936661
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可