Effect of Host Factors on Neutrophil Functions in Response to Burkholderia pseudomallei in Healthy Thai Subjects

• Saengmuang Pornpun

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

• Kewcharoenwong Chidchamai

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

• Tippayawat Patcharaporn

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

• Nithichanon Arnone

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

• Buddhisa Surachat

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

• Lertmemongkolchai Ganjana

  The Centre for Research & Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University

書誌事項

タイトル別名

• Effect of Host Factors on Neutrophil Functions in Response to <i>Burkholderia pseudomallei</i> in Healthy Thai Subjects

抄録

Burkholderia pseudomallei is an intracellular pathogenic bacterium that causes melioidosis in humans. On infection, neutrophils eliminate the majority of intracellular B. pseudomallei. Previous reports on the risk factors for melioidosis have shown that host factors, particularly age and diabetes mellitus, increase susceptibility to B. pseudomallei; however, whether these factors influence neutrophil functions in response to infection remains unknown. In this study, whole blood samples were collected from healthy Thai blood donors and co-cultured with B. pseudomallei, and phagocytic and respiratory burst functions of neutrophils were then measured by flow cytometry. The results show reduced neutrophil functions in older donors or those with poor glycemic control. Furthermore, the levels of antibody against B. pseudomallei showed a positive correlation with neutrophil functions. This study therefore indicated the importance of age, glycemic control, and antibody levels in the activity of neutrophils in melioidosis.

収録刊行物

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 67 (6), 436-440, 2014

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

キーワード

• neutrophils
• melioidosis
• <i>Burkholderia pseudomallei</i>

詳細情報

• CRID: 1390282681218239232
• NII論文ID: 130004712735
• NII書誌ID: AA1132885X
• DOI: 10.7883/yoken.67.436
• ISSN: 18842836
• ISSN: 13446304
• NDL書誌ID: 025937842
• PubMed: 25410558
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025937842
• Web Site: https://search.jamas.or.jp/link/ui/2015279329
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可