Pycnogenol Supplementation Promotes Lipolysis via Activation of cAMP-Dependent PKA in ob/ob Mice and Primary-Cultured Adipocytes
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- HO Jin-Nyoung
- Department of Medical Nutrition, Kyung Hee University
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- KIM Ok-Kyung
- Department of Medical Nutrition, Kyung Hee University
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- NAM Da-Eun
- Department of Medical Nutrition, Kyung Hee University
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- JUN Woojin
- Department of Food and Nutrition, Chonnam National University
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- LEE Jeongmin
- Department of Medical Nutrition, Kyung Hee University Research Institute of Medical Nutrition, Kyung Hee University
書誌事項
- タイトル別名
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- Pycnogenol Supplementation Promotes Lipolysis via Activation of cAMP-Dependent PKA in <i>ob/ob</i> Mice and Primary-Cultured Adipocytes
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This study investigated the PKA-dependent inhibitory effect of pycnogenol (Pyc) on lipolysis using ob/ob mice and primary mouse adipocytes. Supplementation of Pyc at 30 mg/kg significantly reduced body weight gain and visceral fat mass. The serum and hepatic triglyceride (TG) and total cholesterol (TC) levels were reduced by Pyc supplementation, and high density lipoprotein (HDL)-cholesterol level significantly increased. In addition, hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) mRNA levels increased with Pyc supplementation in adipose tissue of ob/ob mice. The treatment of primary cultured adipocytes with Pyc at 100 μg/mL significantly increased glycerol release, cAMP level by reduction of phosphodiestersae-3B (PDE3B), and HSL levels, but decreased protein levels of perilipin A and fatty acid synthetase (FAS). The PKA inhibitor (H89) clearly blocked the cellular levels of perilipin A and HSL, suggesting that Pyc promotes lipolysis of adipocytes through activation of cAMP-dependent PKA, resulting in induction of HSL and reduction of perilipin A. Therefore, this study may elucidate the possible mechanism of Pyc, which is a candidate for weight loss through stimulation of lipolysis.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 60 (6), 429-435, 2014
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詳細情報 詳細情報について
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- CRID
- 1390282681300744704
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- NII論文ID
- 130005060913
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 026008040
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- PubMed
- 25866307
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可