Application of BCBB/BMP/bFGF Complex in Repairing Femoral Head Necrosis in Rabbit Models

DOI Web Site 参考文献17件
  • Peng Wuxun
    Department of Emergency Surgery, Guiyang Medical College
  • Wang Lei
    Department of Emergency Surgery, Guiyang Medical College
  • Deng Jin
    Department of Emergency Surgery, Guiyang Medical College
  • Gong Yuekun
    The First Affiliated Hospital of Kunming Medical College
  • Li Shihe
    The First Affiliated Hospital of Kunming Medical College
  • Hu Yunyu
    Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University

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The purpose of this study was to investigate the efficacy of a mixture of biphasic ceramic biologic bone (BCBB), bone morphogenetic protein (BMP), and basic fibroblast growth factor (bFGF) in repairing femoral head necrosis (FHN) and to explore new FHN treatment. BCBB was modified and mixed with BMP and bFGF to obtain the complex used in this study. The FHN models were implanted with BCBB/BMP mixture, BCBB/BMP/bFGF complex, and cancellous bone autografts, respectively. The control group received no treatment. A series of examinations, including anatomical observation, X-ray examination, histological analysis, and vascular immunohistochemical staining, were carried out 2 w, 4 w, 8 w, and 12 w after operation to assess the repairing of FHN in these groups. Anatomical observation and X-ray examination showed that the complex of BCBB/BMP/bFGF led to the repair of the injuries in these rabbit FHN models, to a comparable level with cancellous bone autografts. Histological analysis indicated that BCBB/BMP/bFGF complex could induce osteoinduction, which would enhance bone remodeling in these models. Furthermore, vascular immunohistochemical staining revealed that BCBB/BMP/bFGF complex dramatically stimulated the revascularization in FHN models, contributing to the injury recovery process. BCBB/BMP/bFGF complex is able to induce obvious osteoinduction and revascularization in rabbit FHN models, to a comparable level as observed with the cancellous bone autografts, thus providing a promising treatment for the disease.

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