Cyclic Sulfoxides-Garlicnins K₁, K₂, and H₁-Extracted from Allium sativum

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  • Nohara Toshihiro
    Faculty of Pharmaceutical Sciences, Sojo University
  • Fujiwara Yukio
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
  • Komota Yusuke
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
  • Kondo Yoshihiko
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
  • Saku Taiki
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
  • Yamaguchi Koki
    Faculty of Pharmaceutical Sciences, Sojo University
  • Komohara Yoshihiro
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
  • Takeya Motohiro
    Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University

書誌事項

タイトル別名
  • Cyclic Sulfoxides-Garlicnins K<sub>1</sub>, K<sub>2</sub>, and H<sub>1</sub>-Extracted from <i>Allium sativum</i>

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抄録

Newly identified cyclic sulfoxides—garlicnins K1 (1), K2 (2), and H1 (3)—were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.

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