Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency : A Double-Blind, 3-Way Crossover Study

DOI Web Site PubMed 被引用文献6件 参考文献31件
  • SUNAGAWA Yoichi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • HIRANO Sae
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka Saiseikai General Hospital
  • KATANASAKA Yasufumi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • MIYAZAKI Yusuke
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • FUNAMOTO Masafumi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • OKAMURA Nobuko
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • HOJO Yuya
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • SUZUKI Hidetoshi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • DOI Osamu
    Shizuoka General Hospital
  • YOKOJI Tsunehiro
    Shizuoka General Hospital
  • MORIMOTO Eriko
    Shizuoka General Hospital
  • TAKAHASHI Tsukasa
    Theravalues Corporation
  • OZAWA Hitomi
    Theravalues Corporation
  • IMAIZUMI Atsushi
    Theravalues Corporation
  • UENO Morio
    Department of Ophthalmology, Kyoto Prefectural University of Medicine
  • KAKEYA Hideaki
    Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
  • SHIMATSU Akira
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • WADA Hiromichi
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • HASEGAWA Koji
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • MORIMOTO Tatsuya
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka General Hospital Division of Translational Research, Kyoto Medical Center, National Hospital Organization

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タイトル別名
  • Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—
  • Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—

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Curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered curcumin to reach blood levels sufficient to exert its bioactivities. To overcome this problem, several curcumin preparations with a drug-delivery system (DDS) have been developed to increase the bioavailability of curcumin after oral administration, and tested as functional foods and potential medical agents in humans. We have also produced capsules containing Theracurmin, curcumin dispersed with colloidal submicron-particles. To evaluate the absorption efficiency of three types of DDS curcumin, we performed a double-blind, 3-way crossover study. We compared plasma curcumin levels after the administration of Theracurmin and 2 other capsule types of curcumin with DDS, BCM-95 (micronized curcumin with turmeric essential oils) and Meriva (curcumin-phospholipid). Nine healthy subjects (male/female=5/4, age: 24-32 y old) were administered these 3 preparations of DDS curcumin, at commonly used dosages. Six capsules of Theracurmin, 1 capsule of BCM-95, and 2 capsules of Meriva contain 182.4±1.0, 279.3±10.7, and 152.5±20.3 mg of curcumin, respectively. The maximal plasma curcumin concentration (0-24 h) of Theracurmin was 10.7 to 5.6 times higher than those of BCM-95 and Meriva, respectively. Moreover, the area under the blood concentration-time curve at 0-24 h was found to be 11.0- and 4.6-fold higher with Theracurmin than BCM-95 and Meriva, respectively. These data indicate that Theracurmin exhibits a much higher absorption efficiency than other curcumin DDS preparations.

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