Irciniastatin A Induces Potent and Sustained Activation of Extracellular Signal-Regulated Kinase and Thereby Promotes Ectodomain Shedding of Tumor Necrosis Factor Receptor 1 in Human Lung Carcinoma A549 Cells

DOI Web Site Web Site PubMed 被引用文献2件 参考文献27件 オープンアクセス
  • Quach Hue Tu
    Department of Applied Biology, Kyoto Institute of Technology
  • Hirano Seiya
    Department of Applied Biology, Kyoto Institute of Technology
  • Fukuhara Sayuri
    Department of Applied Biology, Kyoto Institute of Technology
  • Watanabe Tsubasa
    Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Kanoh Naoki
    Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Iwabuchi Yoshiharu
    Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Usui Takeo
    Faculty of Life and Environmental Sciences, University of Tsukuba
  • Kataoka Takao
    Department of Applied Biology, Kyoto Institute of Technology

この論文をさがす

抄録

Irciniastatin A is a pederin-type marine product that potently inhibits translation. We have recently shown that irciniastatin A induces ectodomain shedding of tumor necrosis factor (TNF) receptor 1 with slower kinetics than other translation inhibitors. In human lung carcinoma A549 cells, irciniastatin A induced a marked and sustained activation of extracellular signal-regulated kinase (ERK) and induced little activation of p38 mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK). Moreover, the TNF receptor 1 shedding induced by irciniastatin A was blocked by the MAP kinase/ERK kinase inhibitor U0126, but not by the p38 MAP kinase inhibitor SB203580 or the JNK inhibitor SP600125. Thus unlike other translation inhibitors that trigger ribotoxic stress response, our results show that irciniastatin A is a unique translation inhibitor that induces a potent and sustained activation of the ERK pathway, and thereby promotes the ectodomain shedding of TNF receptor 1 in A549 cells.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (27)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ