Anatomy : Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos

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  • UEMURA Mami
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan
  • IGARASHI Hitomi
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan
  • OZAWA Aisa
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan
  • TSUNEKAWA Naoki
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan
  • KUROHMARU Masamichi
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan
  • KANAI-AZUMA Masami
    Center for Experimental Animals, Tokyo Medical and Dental University, 1–5–45 Yushima, Bunkyo-ku, Tokyo 113–8510, Japan
  • KANAI Yoshiakira
    Department of Veterinary Anatomy, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

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  • Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos

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In early embryogenesis, the posteroventral foregut endoderm gives rise to the budding endodermal organs including the liver, ventral pancreas and gallbladder during early somitogenesis. Despite the detailed fate maps of the liver and pancreatic progenitors in the mouse foregut endoderm, the exact location of the gallbladder progenitors remains unclear. In this study, we performed a DiI fate-mapping analysis using whole-embryo cultures of mouse early somite-stage embryos. Here, we show that the majority of gallbladder progenitors in 9–11-somite-stage embryos are located in the lateral-most domain of the foregut endoderm at the first intersomite junction level along the anteroposterior axis. This definition of their location highlights a novel entry point to understanding of the molecular mechanisms of initial specification of the gallbladder.

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