Laboratory Animal Science : CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice

DOI Web Site PubMed 参考文献17件
  • HONG Yu Ri
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
  • LEE Hyun
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
  • PARK Min Hee
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
  • LEE Jong Kil
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
  • LEE Ju Youn
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
  • SUH Hwa Deok
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
  • JEONG Min Seock
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea
  • BAE Jae-Sung
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea
  • JIN Hee Kyung
    Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu, Korea Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea

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  • CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice

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Niemann-Pick type C disease (NP-C) is a rare and ultimately fatal lysosomal storage disorder with variable neurologic symptoms. Loss of neuronal function and neuronal cell death occur in the NP-C brain, similar to the findings for other neurodegenerative diseases. Targeting of neuronal cells in the brain therefore represents a potential clinical intervention strategy to reduce the rate of disease progression and improve the quality of life. We previously reported that bone marrow stem cells show a neurogenic effect through CCL2 (also known as monocyte chemoattractant protein-1, MCP-1) secretion in the brains of NP-C mice. However, the direct effect of CCL2 on neurogenesis has not been ascertained. Here, to define neurogenic effects of CCL2 in NP-C, we applied human recombinant CCL2 to neural stem cells (NSCs) derived from NP-C mice. CCL2-treated NSCs showed significantly increased capacity for self-renewal, proliferation and neuronal differentiation. Similar results were observed in the subventricular zone of NP-C mice after CCL2 treatment. Furthermore, infusion of CCL2 into the NP-C mouse brain resulted in reduction of neuroinflammation. Taken together, our results demonstrate that CCL2 is a potential new therapeutic agent for NP-C.

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