Cytotoxic Biscembranoids from the Soft Coral Sarcophyton pauciplicatum

DOI Web Site Web Site PubMed 参考文献13件
  • Nam Nguyen Hoai
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Tung Pham The
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) School of Chemical Engineering, Hanoi University of Science and Technology
  • Ngoc Ninh Thi
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Hanh Tran Thi Hong
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Thao Nguyen Phuong
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Thanh Nguyen Van
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Cuong Nguyen Xuan
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Thao Do Thi
    Institute of Biotechnology, VAST
  • Huong Tran Thu
    School of Chemical Engineering, Hanoi University of Science and Technology
  • Thung Do Cong
    Institute of Marine Environment and Resources, VAST
  • Kiem Phan Van
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
  • Kim Young Ho
    College of Pharmacy, Chungnam National University
  • Minh Chau Van
    Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

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タイトル別名
  • Cytotoxic Biscembranoids from the Soft Coral <i>Sarcophyton pauciplicatum</i>

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抄録

Ten biscembranoids (1–10), including the two new compounds sarcophytolides M and N (1 and 2), were isolated from the methanol extract of the Vietnamese soft coral Sarcophyton pauciplicatum. Their structures were elucidated by spectroscopic methods including one dimensional (1D)- and 2D-NMR, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and circular dichroism (CD). The in vitro cytotoxic activity of all isolated compounds against a panel of eight human cancer cell lines including HepG2 (hepatoma cancer), HL-60 (acute leukemia), KB (epidermoid carcinoma), LNCaP (prostate cancer), LU-1 (lung cancer), MCF7 (breast cancer), SK-Mel2 (melanoma), and SW480 (colon adenocarcinoma) was evaluated using the sulforhodamine B colorimetric assay. Among the isolated biscembranoids, 1, 3, 4, 7, 9, and 10 exhibited significant cytotoxic effects and may be selected for further studies of their anticancer activity.

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