Inhibitory Effects of Caffeic Acid, a Coffee-Related Organic Acid, on the Propagation of Hepatitis C Virus

• Tanida Isei

  Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases

• Shirasago Yoshitaka

  Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases Research Institute for Biomedical Sciences, Tokyo University of Science

• Suzuki Ryosuke

  Department of Virology II, National Institute of Infectious Diseases

• Abe Ryo

  Research Institute for Biomedical Sciences, Tokyo University of Science

• Wakita Takaji

  Department of Virology II, National Institute of Infectious Diseases

• Hanada Kentaro

  Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases

• Fukasawa Masayoshi

  Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases

抄録

Multipurpose cohort studies have demonstrated that coffee consumption reduces the risk of hepatocellular carcinoma (HCC). Given that one of the main causes of HCC is hepatitis C virus (HCV) infection, we examined the effect of caffeic acid, a major organic acid derived from coffee, on the propagation of HCV using an in vitro naïve HCV particle-infection and production system within human hepatoma-derived Huh-7.5.1-8 cells. When cells were treated with 1% coffee extract or 0.1% caffeic acid for 1-h post HCV infection, the amount of HCV particles released into the medium at 3 and 4 days post-infection considerably decreased. In addition, HCV-infected cells cultured with 0.001% caffeic acid for 4 days, also released less HCV particles into the medium. Caffeic acid treatment inhibited the initial stage of HCV infection (i.e., between virion entry and the translation of the RNA genome) in both HCV genotypes 1b and 2a. These results suggest that the treatment of cells with caffeic acid may inhibit HCV propagation.

収録刊行物

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 68 (4), 268-275, 2015

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

キーワード

• coffee
• caffeic acid
• hepatocellular carcinoma
• chlorogenic acid
• HCV

詳細情報

• CRID: 1390282681218608512
• NII論文ID: 130005088796
• NII書誌ID: AA1132885X
• DOI: 10.7883/yoken.jjid.2014.309
• ISSN: 18842836
• ISSN: 13446304
• NDL書誌ID: 026618213
• PubMed: 25672401
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026618213
• Web Site: https://search.jamas.or.jp/link/ui/2016248554
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可