Effect of Kiwifruit on Bone Resorption in Ovariectomized Mice

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  • KATSUMATA Shinichi
    Institute of Food, Nutrition and Human Health, Massey University Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • WOLBER Frances M.
    Institute of Food, Nutrition and Human Health, Massey University
  • TADAISHI Miki
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture Department of Food Function and Labeling, National Institute of Health and Nutrition
  • TOUSEN Yuko
    Department of Food Function and Labeling, National Institute of Health and Nutrition
  • ISHIMI Yoshiko
    Department of Food Function and Labeling, National Institute of Health and Nutrition
  • KRUGER Marlena C.
    Institute of Food, Nutrition and Human Health, Massey University

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Kiwifruit is a good source of dietary components and has beneficial effects for health. In this study, we investigated the effects of two types of kiwifruit, green kiwifruit (GRK) and gold kiwifruit (GOK), on bone metabolism in ovariectomized (OVX) mice. Seven-week-old female Balb/c-strain mice were divided into four groups: sham-operated (sham) group, OVX group, and OVX mice that were fed a GRK-supplemented diet or GOK-supplemented diet. Freeze-dried GRK and GOK were prepared and added in the diet at a concentration of 3 g/100 g. After 9 wk, the mice were sacrificed, and the serum, uterus, and femurs were obtained. Final body weight did not differ significantly among the four groups. Compared to the sham group, uterine weight was significantly lower and serum C-terminal telopeptide of type I collagen (CTx) levels and receptor activator of NF-κB ligand (RANKL) mRNA expression of the whole femur were significantly higher in the OVX group. Compared to the OVX group, GRK, but not GOK, reduced serum CTx concentrations and RANKL mRNA expression of the whole femur without changes in uterine weight. These results suggest that the GRK inhibited bone resorption, which might be due to a decrease in RANKL mRNA expression in OVX mice.

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