iMap-Intravascular Ultrasound Radiofrequency Signal Analysis Reflects Plaque Components of Optical Coherence Tomography-Derived Thin-Cap Fibroatheroma

• Koga Seiji

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Ikeda Satoshi

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Miura Miyuki

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Yoshida Takeo

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Nakata Tomoo

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Koide Yuji

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Kawano Hiroaki

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Maemura Koji

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

抄録

Background:The ability of iMap-intravascular ultrasound (IVUS) tissue characterization to detect thin-cap fibroatheroma (TCFA) identified on optical coherence tomography (OCT) has not yet been fully elucidated.Methods and Results:We evaluated 86 coronary lesions from 73 patients with stable angina pectoris using iMap-IVUS and OCT. We defined OCT-derived TCFA (OCT-TCFA) as lipid-rich plaque with a <65-μm-thick fibrous cap. The external elastic membrane (EEM) cross-sectional area (CSA), lumen CSA, plaque plus media (P+M) CSA, plaque burden and remodeling index were measured on gray-scale IVUS. Plaque components categorized on iMap-IVUS as fibrotic, lipidic, necrotic or calcified are presented as absolute area and proportion (%) of total plaque area. OCT-TCFA (22 lesions) had significantly greater EEM CSA, P+M CSA, plaque burden and remodeling index than non-TCFA (64 lesions). Significantly larger %necrotic area, absolute lipidic and necrotic areas and smaller %fibrotic areas were found in OCT-TCFA than in non-TCFA. On multivariate analysis, absolute necrotic area was an independent predictor of OCT-TCFA. The area under the ROC curve for absolute necrotic area required to identify OCT-TCFA was 0.86. The sensitivity, specificity, positive and negative predictive values of absolute necrotic area ≥7.3 mm²for identifying OCT-TCFA were 77%, 88%, 68% and 92%, respectively.Conclusions:Coronary lesions with greater iMap-IVUS absolute necrotic area were closely associated with OCT-TCFA. (Circ J 2015; 79: 2231–2237)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (10), 2231-2237, 2015

  一般社団法人 日本循環器学会

キーワード

• Angina pectoris
• Intracoronary imaging
• Tissue characterization

詳細情報

• CRID: 1390001205106756608
• NII論文ID: 130005099856
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-15-0393
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026750072
• PubMed: 26289833
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026750072
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/10/79_CJ-15-0393/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016200715
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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