鼻茸を伴うアレルギー性鼻炎疑い例に対するサルコート<sup>®</sup>鼻内噴霧の使用経験

DOI Web Site Web Site 参考文献3件

書誌事項

タイトル別名
  • Treatment with Salcoat<sup>®</sup> Nasal Spray for Nasal Polyps Associated with Allergic Rhinitis
  • 薬物 鼻茸を伴うアレルギー性鼻炎疑い例に対するサルコート鼻内噴霧の使用経験
  • ヤクブツ ハナタケ オ トモナウ アレルギーセイ ビエン ウタガイ レイ ニ タイスル サルコート ビ ナイ フンム ノ シヨウ ケイケン

この論文をさがす

抄録

Beclometasone (product name: Salcoat®) for oral spray is a powder formulation containing a large amount of a mucosal-adhesive base material (hydroxypropyl cellulose: HPC), which allows the drug to be retained longer at the local site. When the product is sprayed on the affected site with a dedicated small sprayer (pubriser®), the HPC gelates by absorbing moisture on the mucosal surface and adheres to the mucosa. As a result, it remains at the affected site for a prolonged period of time and thereby also releases the active ingredient (steroid) locally for a prolonged period of time.<br>Treatment with Salcoat® nasal spray (one puff in each nostril, twice daily) was given to 10 patients with nasal polyps associated with allergic rhinitis who showed no improvement with conservative treatment for one year or longer. Subjective improvement in the feeling of nasal congestion was observed in 7 cases and the nasal polyps shrank in 5 cases.<br>Treatment with Salcoat® was prematurely discontinued in one patient because nasal congestion occurred immediately after the formulation was sprayed, due to gelation of the drug. None of the patients showed any signs of mycosis.

収録刊行物

参考文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ