書誌事項
- タイトル別名
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- Synthesis and Properties of 2’,4’-Bridged Nucleic Acids Containing Multiple Heteroatoms in the Bridges
- カケハシブ ニ フクスウ ノ ヘテロ ゲンシ オ ユウスル 2',4'-カケハシガタ ジンコウ カクサン ノ ゴウセイ ト キノウ
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Nucleic acids bridged between 2’- and 4’-positions are attracting much attention because the oligonucleotides bearing these derivatives generally increase in the binding affinity with single-stranded RNA and have an increased resistance against nuclease. It is found that their properties are greatly affected by size and composition of the bridge. In particular, introduction of heteroatom into the bridge unit is considered to give an influence on network of surrounding water molecules in formation of nucleic acid complex. Therefore, it would be meaningful to investigate and understand the properties of various 2’,4’-bridged nucleic acids. Under such a background, this account focuses on 2’,4’-bridged nucleic acids containing multiple heteroatoms in the bridge structures, with five-, six- and seven-membered bridges, have recently been reported by us, and the synthesis, duplex-forming ability with single-stranded nucleic acid and nuclease resistance of their modified oligonucleotides are mainly described.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 74 (2), 141-153, 2016
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680317298944
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- NII論文ID
- 130005138527
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 027099974
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可