Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients

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  • PIRABBASI Elham
    Dietetic Programme, Center for Health Care Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia
  • SHAHAR Suzana
    Dietetic Programme, Center for Health Care Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia
  • MANAF Zahara Abdul
    Dietetic Programme, Center for Health Care Sciences, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia
  • RAJAB Nor Fadilah
    Department of Biomedicine, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia
  • MANAP Roslina Abdul
    Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia

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Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients. This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centers in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC+vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90% and significance level of p<0.05. Repeated Measure ANOVA showed that there was a significant interaction effect on BMI (p=0.046) and carbohydrate intake (p=0.030), especially in the NAC group. Plasma glutathione (GSH) increased significantly in all intervention groups, especially in vitamin C (p=0.005). A single supplementation of NAC or vitamin C improved nutritional and antioxidant status of subjects.

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