Effect of Food Thickener on Dissolution and Laxative Activity of Magnesium Oxide Tablets in Mice
-
- Tomita Takashi
- Department of Pharmacy, Hospital Bando
-
- Goto Hidekazu
- Department of Pharmacy, Hospital Bando
-
- Yoshimura Yuya
- Pharmaceutical Division, Kyowa Chemical Industry Co., Ltd.
-
- Kato Kazushige
- Pharmaceutical Division, Kyowa Chemical Industry Co., Ltd.
-
- Yoshida Tadashi
- Department of Internal Medicine, Hospital Bando
-
- Tanaka Katsuya
- Department of Psychiatry, Hospital Bando
-
- Sumiya Kenji
- Faculty of Pharmacy, Iwaki Meisei University
-
- Kohda Yukinao
- Department of Pharmacy, Hospital Bando Faculty of Health Sciences, Tsukuba International University
この論文をさがす
抄録
The present study examined the dissolution of magnesium oxide (MgO) from MgO tablets placed in a food thickening agent (food thickener) and its effects on laxative activity. We prepared mixtures of MgO tablets suspended in an aqueous suspension and food thickeners in order to evaluate the dissolution of MgO. The results of the dissolution tests revealed that agar-based food thickeners did not affect the MgO dissolution. In contrast, some xanthan gum-based food-thickener products show dissolution rates with certain mixtures containing disintegrated MgO tablets suspended in a food thickener that decrease over time. However, other xanthan gum-based food-thickener products show dissolution rates that decrease immediately after mixing, regardless of the time they were allowed to stand. In order to investigate the laxative activity of MgO, we orally administered a mixture of MgO suspension and food thickener to mice and observed their bowel movements. The animal experiments showed that when agar-based food thickeners were used, the laxative activity of MgO was not affected, but it decreased when xanthan gum-based food thickeners were used.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 39 (4), 648-651, 2016
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679608473600
-
- NII論文ID
- 130005141677
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 027221297
-
- PubMed
- 27040638
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可