Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases

• Wei Wang

• Yoshinori Hirano

• Takanori Uzawa

• Makoto Taiji

• Yoshihiro Ito

抄録

Conjugation of small molecular inhibitor with a site recognition peptide would generate highly potent peptide–drug conjugate inhibitors of protein kinases. A peptide selected by ribosome display with a tRNA carrying an inhibitor-conjugated amino acid exhibited up to 10- to 100-fold higher inhibitory effects towards different kinases than solely the inhibitor.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 89 (4), 444-446, 2016-04

  Tokyo : Chemical Society of Japan

キーワード

• General Chemistry

詳細情報

• CRID: 1520291855159800320
• NII論文ID: 130005144950
• NII書誌ID: AA00580132
• ISSN: 00092673
• ISSN: 13480634
• DOI: 10.1246/bcsj.20150414
• NDL書誌ID: 027243266
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027243266
• Web Site: https://academic.oup.com/bcsj/article-pdf/89/4/444/56278811/bcsj.20150414.pdf
• 本文言語コード: en
• NDL 雑誌分類:
  • ZP1(科学技術--化学・化学工業)
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