Application of Photobiomodulation to Light Therapy for the Central Nervous System Disease: Control of Spreading Depolarization
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- KAWAUCHI Satoko
- Div. of Biomedical Information Sciences, National Defense Medical College Research Institute
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- NISHIDATE Izumi
- Graduate School of Bio-Applications & Systems Engineering, Tokyo University of Agriculture and Technology
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- NAWASHIRO Hiroshi
- Div. of Neurosurgery, Tokorozawa Central Hospital
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- SATO Shunichi
- Div. of Biomedical Information Sciences, National Defense Medical College Research Institute
Bibliographic Information
- Other Title
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- 低出力光の中枢神経疾患治療への応用:拡延性脱分極の制御
- テイシュツリョク ヒカリ ノ チュウスウ シンケイ シッカン チリョウ エ ノ オウヨウ : カクエンセイ ダツブンキョク ノ セイギョ
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Abstract
Anoxic depolarization( AD), which is caused by ischemia/hypoxia in brain, is known to trigger neuronal cell death. Energy restoration would be needed for preventing the occurrence of AD and resultant cell death. Photobiomodulation therapy, in which low-intensity light with a specific wavelength is used for mitochondria, can enhance energy production in neuronal cells under pathophysiological conditions. In this study, we examined whether visible (665 nm) or near-infrared (808 nm) laser irradiation can control the occurrence of AD in rat brain. At both wavelengths, the onset of AD was significantly delayed in the light-treated hemisphere when compared with that in the non-treated hemisphere (n=8). The spreading area of AD was also significantly smaller in the light-treated hemisphere than in the nontreated hemisphere. These results suggest that photobiomodulation therapy can control AD in the brain, which is probably due to an increase in ATP by laser irradiation.
Journal
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- The Review of Laser Engineering
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The Review of Laser Engineering 44 (4), 250-, 2016
The Laser Society of Japan
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Details 詳細情報について
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- CRID
- 1390286981360470656
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- NII Article ID
- 130007957206
- 40020834094
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- NII Book ID
- AN00255326
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- ISSN
- 13496603
- 03870200
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- NDL BIB ID
- 027320285
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed