Locomotor-Reducing Activity of Sesquiterpenes Related to Zingiber zerumbet Essential Oil and Hexahydrozerumbone Derivatives
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- Ogawa Kakuyou
- Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Yabe Hironobu
- Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University
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- Kitayama Takashi
- Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University
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- Ito Michiho
- Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University
書誌事項
- タイトル別名
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- Locomotor-Reducing Activity of Sesquiterpenes Related to <i>Zingiber zerumbet</i> Essential Oil and Hexahydrozerumbone Derivatives
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抄録
Zerumbone derivatives 1–4 are 11-membered cyclic compounds synthesised from a sesquiterpene zerumbone obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the locomotor-reducing effects of hexahydrozerumbone derivatives 1–3 and zerumbol 4, and those of β-caryophyllene 5 and caryophyllene oxide 6, which are present in Z. zerumbet essential oil. The absence of the double bond at C6 weakened the locomotor-reducing effects. β-Caryophyllene 5 and caryophyllene oxide 6 showed locomotor-reducing effects in mice at 4.5×10−3 mg/cage. Moreover, locomotor activity increased significantly at 0.45 mg/cage of caryophyllene oxide 6.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 39 (6), 1077-1080, 2016
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609917696
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- NII論文ID
- 130005155123
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 2433/244283
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- NDL書誌ID
- 027325550
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- PubMed
- 27251513
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可