1歳男児の下顎骨に生じたLangerhans’-cell histiocytosisの1例

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  • 吉住 潤子
    九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野 公立学校共済組合九州中央病院歯科口腔外科
  • 熊丸 渉
    九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野
  • 窪田 泰孝
    九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野 国家公務員共済組合連合会佐世保共済病院歯科口腔外科
  • 矢内 理沙
    九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野
  • 清島 保
    九州大学歯学研究院口腔顎顔面病態学講座口腔病理学分野
  • 森 悦秀
    九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野

書誌事項

タイトル別名
  • A case of Langerhans’-cell histiocytosis of the mandible in a 1-year-old boy
  • 1サイ ダンジ ノ カガクコツ ニ ショウジタ Langerhans'-cell histiocytosis ノ 1レイ

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抄録

Langerhans’-cell histiocytosis (LCH) is a relatively rare proliferative disorder of Langerhans’ cells with unknown etiology 1～3）. LCH can occur throughout the body, and cases have been reported in the skin, liver, spleen, lung, lymph nodes, and bone. We present a case of LCH in a 1-year-old boy who presented with fever and swelling of the right cheek. Radiographic examinations revealed expansion of the mandibular molar region with destruction of the cortex. Because such findings might mimic a malignant tumor, we made a clinical diagnosis of mandibular tumor. After confirming the pathological diagnosis, chemotherapy was performed according to the protocol of the Japan LCH study group. No recurrence was noted during a 3-year follow-up period. However, in infants, hypoplasia of the teeth can occur as a side effect of chemotherapy or a direct effect of the tumor itself. Long-term follow-up in cooperation with pediatricians and pedodontists is recommended for infants with LCH.

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