Antibacterial Meroterpenoids from the South China Sea Sponge Dysidea sp

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  • Zhang Xia
    Department of Pharmacy, People’s Hospital of Linzi District
  • Xu Hong-Yan
    Department of Pharmacy, People’s Hospital of Linzi District
  • Huang Ai-Mei
    Department of Pharmacy, People’s Hospital of Linzi District
  • Wang Lei
    Department of Pharmacy, People’s Hospital of Linzi District
  • Wang Qiang
    Department of Pharmacy, People’s Hospital of Linzi District
  • Cao Peng-Yun
    Department of Pharmacy, People’s Hospital of Linzi District Department of Pharmacy, Shandong University of Traditional Chinese Medicine
  • Yang Pei-Min
    Department of Pharmacy, People’s Hospital of Linzi District

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タイトル別名
  • Antibacterial Meroterpenoids from the South China Sea Sponge <i>Dysidea</i> sp.

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Chemical investigation of the sponge Dysidea sp. afforded three new sesquiterpene phenols (1–3) and one new sesquiterpene aminoquinone (4), together with four known sesquiterpene derivatives (5–8). The structures of all compounds were unambiguously elucidated by extensive spectroscopic analysis, as well as by comparison with the literature. The absolute configurations of compounds 1–4 were determined by electron capture detector (ECD) calculations and circular dichroism (CD) spectrum analysis. Their antibacterial activity against Escherichia coli (25922), Bacillus subtilis (6633), and Staphylococcus aureus (25923) were evaluated. Compounds 1 and 3 showed weak antibacterial activity against the above three strains, whereas compounds 4–8 showed potent antibacterial activities with minimum inhibitory concentration (MIC) values in the range of 3.125 to 12.5 µg/mL.

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