Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

DOI Web Site Web Site PubMed 参考文献46件
  • Zhang Nannan
    MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University
  • Li Zhongchi
    MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University
  • Xu Kang
    MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University
  • Wang Yanying
    MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University Peking Union Medical College
  • Wang Zhao
    MOE Key Laboratory of Protein Sciences, Department of Pharmacology, School of Medicine, Tsinghua University

この論文をさがす

抄録

<p>Obesity-related renal diseases have been a worldwide issue. Effective strategy that prevents high fat-diet induced renal damage is of great significance. Resveratrol, a natural plant polyphenol, is famous for its antioxidant activity, cardioprotective effects and anticancer properties. However whether resveratrol can play a role in the treatment of renal diseases is unknown. In this study, we added resveratrol in normal glucose or high glucose medium and provide evidences that resveratrol protects against high-glucose triggered oxidative stress and cell senescence. Moreover, mice were fed with standard diet, standard diet plus resveratrol, high-fat diet or high-fat diet plus resveratrol for 3 months, and results show that resveratrol treatment prevents high-fat diet induced renal pathological damage by activating SIRT1, a key member in the mammalian sirtuin family that response to calorie restriction life-extension method. This research confirms the potential role of resveratrol in the treatment of renal diseases and may provide an effective and convenient method to mimic the beneficial effects of calorie restriction.</p>

収録刊行物

参考文献 (46)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ