Salt Intake, Home Blood Pressure, and Perinatal Outcome in Pregnant Women

• Inoue Minako

  Clinical Research Institute, National Hospital Organization Kyushu Medical Center Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Tsuchihashi Takuya

  Clinical Research Institute, National Hospital Organization Kyushu Medical Center Steel Memorial Yawata Hospital

• Hasuo Yasuyuki

  Division of Obstetrics and Gynecology, National Hospital Organization Kyushu Medical Center

• Ogawa Masanobu

  Division of Obstetrics and Gynecology, National Hospital Organization Kyushu Medical Center

• Tominaga Mitsuhiro

  Division of Hypertension, National Hospital Organization Kyushu Medical Center

• Arakawa Kimika

  Division of Clinical Laboratory, National Hospital Organization Kyushu Medical Center

• Oishi Emi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Sakata Satoko

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Ohtsubo Toshio

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Matsumura Kiyoshi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Kitazono Takanari

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

抄録

Background:The relationship between salt (sodium chloride) intake and pregnancy-induced hypertension (PIH) remains unclear. The aim of this study was therefore to investigate the current status of salt intake during pregnancy and identify effective predictors for PIH. Methods and Results:Participants were 184 pregnant women who collected 24-h home urine as well as early morning urine samples. We investigated urinary salt excretion, home blood pressure (HBP) measurements for 7 consecutive days before the 20th and after the 30th gestational week, and the development of PIH. Urinary salt excretion according to early morning urine before the 20th gestational week was 8.6±1.7 g/day, and was significantly correlated with that measured from 24-h collected urine. Early morning urine estimated urinary salt excretion was slightly but significantly increased during pregnancy. HBP was 102±10/63±8 mmHg before the 20th gestational week and 104±12/64±10 mmHg after the 30th gestational week. On multiple regression analysis, serum uric acid and body mass index, but not urinary salt excretion, contributed to HBP both before the 20th and after the 30th gestational week. Fourteen participants (7.6%) developed PIH. On multivariate analysis, higher HBP and older age, but not urinary salt excretion, were significantly associated with PIH. Conclusions:Higher HBP and older age, but not urinary salt excretion, are predictors of PIH. (Circ J 2016; 80: 2165–2172)

収録刊行物

• Circulation Journal

  Circulation Journal 80 (10), 2165-2172, 2016

  一般社団法人 日本循環器学会

キーワード

• Blood pressure
• Pre-eclampsia
• Pregnancy
• Salt intake
• Uric acid

詳細情報

• CRID: 1390282680083440896
• NII論文ID: 130005419001
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-16-0405
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 027611932
• PubMed: 27568849
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027611932
• Web Site: https://www.jstage.jst.go.jp/article/circj/80/10/80_CJ-16-0405/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可