Anti-Hyperglycemic Effect of a Kudzu (Pueraria lobata) Vine Extract in Ovariectomized Mice

DOI Web Site Web Site PubMed 被引用文献1件 参考文献31件
  • TANAKA Teruyoshi
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
  • YOKOTA Yukihiro
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
  • TANG Hanjun
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
  • ZAIMA Nobuhiro
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
  • MORIYAMA Tatsuya
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
  • KAWAMURA Yukio
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University

書誌事項

タイトル別名
  • Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

この論文をさがす

抄録

Postmenopausal diabetes is exacerbated by estrogen deficiency. Ovariectomized (OVX) animal models can be used to develop strategies for preventing or treating postmenopausal symptoms. We previously found that a diet containing kudzu (Pueraria lobata) vine ethanol extract (PVEE) suppressed weight gain in OVX mice. Therefore, this study further elucidated how PVEE affected OVX mice. Ten-week-old OVX or sham-operated mice were fed diets containing either no PVEE (control) or 20 mg•kg−1•d−1 PVEE for 8 wk, 5 mg•kg−1•d−1 PVEE for 24 wk, or 20 mg•kg−1•d−1 puerarin (daidzein-8-C-glucoside), a major isoflavone present in PVEE, for 10 wk. The effects of puerarin on glucose tolerance were also tested in OVX mice. The experimental diets were not associated with any abnormalities in any mice tested in the present study. Weight gain and serum glucose levels were increased in OVX mice and these effects were significantly attenuated in OVX mice that consumed PVEE (5 or 20 mg•kg−1•d−1) or puerarin. Puerarin-treated OVX mice also showed reduced serum glucose levels following administration of 1,000 mg•kg−1 glucose. These results suggested that puerarin contributed to PVEE-mediated improvements in glucose metabolism in OVX mice. Although further studies are needed to clarify the molecular mechanism underlying these observations, PVEE and puerarin could provide effective approaches to the amelioration of postmenopausal diabetes.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (31)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ