Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

• Al-Ali Khalil

  Medical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University

• Abdel Fatah Hala Salah

  Biochemistry Laboratory, Biochemistry and Nutrition Department, Faculty of Women’s for Arts, Science and Education, Ain Shams University

• El-Badry Yaser Abdel-Moemen

  Organic Chemistry Laboratory, Faculty of Specific Education, Ain Shams University Organic Chemistry Department, Faculty of Science, Taif University

抄録

Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin–zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin–Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin–Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39 (11), 1774-1780, 2016

  公益社団法人 日本薬学会

キーワード

• diabetes
• curcumin–zinc complex
• dual action
• curcumin
• zinc metal
• diabetes complication

詳細情報

• CRID: 1390282679611027840
• NII論文ID: 130005268573
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b16-00137
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 027685335
• PubMed: 27803448
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027685335
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/11/39_b16-00137/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017175797
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可