Effects of Low-intensity Pulsed Ultrasound on Healing after Maxillary Sinus Augmentation in Rabbits
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- Takebe Hiroaki
- Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
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- Nakanishi Yasuhiro
- Division of Fixed Prosthodontics and Oral Implantology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
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- Hirose Yukito
- Division of Fixed Prosthodontics and Oral Implantology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
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- Wang Pao-Li
- Department of Bacteriology, Osaka Dental University
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- Irie Kazuharu
- Division of Histology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
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- Ochi Morio
- Division of Fixed Prosthodontics and Oral Implantology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
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抄録
Low-intensity pulsed ultrasound stimulation (LIPUS) is used in orthopedics as a supplementary therapy to promote the healing of pathological and traumatic fractures, and has also been used in dental implant surgery. Little research exists on the effects of ultrasound on maxillary sinus augmentation, and the mechanisms involved in this process remain unclear. The purpose of the present study was to determine the optimal frequency for enhancing bone regeneration in sinus augmentation by measuring cell proliferation via bromodeoxyuridine (BrdU) analysis in a rabbit model. Forty male rabbits underwent bilateral sinus augmentation in the nasal bone. LIPUS was applied to the experimental sites at two different frequencies (1 and 3 MHz) daily for 1, 2, 4 and 8 weeks. Each histological area of the experimental and control sites was divided into an upper and lower portion from the parietal region to a depth of 5 mm. Immunoreactive nucleated cells were counted by BrdU analysis in each of the three measured areas (1 × 1 mm squares) in the experimental and control sites. The labeling index was defined as the number of BrdU-labeled nuclei divided by the total number of nuclei and was expressed as a percentage. At 1 and 2 weeks, the experimental sites in the 1 MHz group exhibited a significantly higher labeling index than the control sites in both the upper and lower portions. At 1, 2, 4 and 8 weeks, no differences were observed in the upper and lower portions between the experimental and control sites in the 3 MHz group. In conclusion, our results suggest that LIPUS enhances cell proliferation in relation to newly formed bone at 1 week following maxillary sinus augmentation; this effect is greater at a frequency of 1 MHz than at 3 MHz.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 25 (4), 395-402, 2016
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001204458199936
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- NII論文ID
- 130005249134
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL書誌ID
- 027699009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- KAKEN
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- 使用不可