Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

• Dang Nguyen Hai

  Advanced Center for Bio-organic Chemistry, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST)

• Chung Nguyen Dinh

  Department of Bioactive Products, IMBC, VAST

• Tuan Ha Manh

  Department of Bioactive Products, IMBC, VAST

• Hiep Nguyen Tuan

  National Institute of Medicinal Materials

• Dat Nguyen Tien

  Department of Bioactive Products, IMBC, VAST

書誌事項

タイトル別名

• Cytotoxic Homoisoflavonoids from <i>Ophiopogon japonicus</i> Tubers

抄録

A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B–D (2–4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC₅₀ values ranging from 0.51 to 0.66 µM.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 65 (2), 204-207, 2017

  公益社団法人 日本薬学会

キーワード

• <i>Ophiopogon japonicus</i>
• homoisoflavanone
• homoisoflavane
• homoisopogon
• cytotoxicity

詳細情報

• CRID: 1390282679153460096
• NII論文ID: 130005306096
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c16-00743
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 027871475
• PubMed: 27916782
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027871475
• Web Site: https://www.jstage.jst.go.jp/article/cpb/65/2/65_c16-00743/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017307761
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可