Effects of Combined Treatment with Branched-Chain Amino Acids, Citric Acid, L-Carnitine, Coenzyme Q10, Zinc, and Various Vitamins in Tumor-Bearing Mice
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- Awa Hiroko
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Futamura Akihiko
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Higashiguchi Takashi
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Ito Akihiro
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Mori Naoharu
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Murai Miyo
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Ohara Hiroshi
- Department of Surgery and Palliative Medicine, School of Medicine, Fujita Health University
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- Chihara Takeshi
- Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University
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- Kaneko Takaaki
- Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University
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抄録
<p>A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9-week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 40 (3), 266-271, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610285696
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- NII論文ID
- 130005398466
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 028005556
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- PubMed
- 28123134
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可