pH応答性薬剤カプセルと粘膜の表面間力に対してカプセル内部の架橋が及ぼす影響のコロイドプローブAFM法による評価

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タイトル別名
  • Characterization of Cross-linking Vehicle Effect on Surface Interactions between pH-sensitive Drug Delivery Vehicle and Mucin Layers by Colloid Probe Atomic Force Microscopy
  • pH オウトウセイ ヤクザイ カプセル ト ネンマク ノ ヒョウメン カンリョク ニ タイシテ カプセル ナイブ ノ カキョウ ガ オヨボス エイキョウ ノ コロイドプローブ AFMホウ ニ ヨル ヒョウカ

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<p>In order to control the interaction between the artificial mucin layer and pH-responsive shells of the core-shell drug delivery vehicles, two types of cross-linking agents with different molecular weights were added to the shells. The surface interaction between each vehicle and mucin was measured by colloid probe atomic force microscopy under different pH conditions. By adding 0.08 mol% cross-linking agents, the shell swelling phenomena at pH > 6 were maintained. Addition of a low molecular weight cross-linking agent (TEGDMA) reduces the interaction distance of repulsive force during approaching process. Addition of a high molecular weight cross-linking agent (PEGDMA) increased the interaction distance of repulsive force. A long interaction distance of attractive force during the separating process disappeared at pH = 6 after the addition of PEGDMA. However, TEGDMA addition maintained the long interaction distance of attractive force at pH = 8, which suggested that the vehicle might remain for an extended duration in the small intestine.</p>

収録刊行物

  • 粉体工学会誌

    粉体工学会誌 54 (5), 305-310, 2017

    一般社団法人 粉体工学会

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