A Novel Strategy for Etiologic Factor Removal: Drug-Navigated Clearance System (DNCS)
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- Mahara Atsushi
- Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute
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- Harada-Shiba Mariko
- Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
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- Yamaoka Tetsuji
- Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute
Bibliographic Information
- Other Title
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- Communications to the Editor : A Novel Strategy for Etiologic Factor Removal : Drug-Navigated Clearance System (DNCS)
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Abstract
<p>Here, we propose a novel therapeutic concept named drug-navigated clearance system (DNCS), in which a “navigator” decreases the concentration of a target etiologic factor in the blood by steering it to an unusual metabolic pathway. The navigator is composed of protein A (ProA) and dextran sulfate (DexS) and it successfully navigated antibodies (ABs), a model etiologic factor of dilated cardiomyopathy, to hepatocytes in vitro in the presence of low-density lipoprotein (LDL). ProA captured the Fc region of the target antibody while the DexS bound to LDL via the well-known electrostatic interaction. The hepatocytes simultaneously took up LDL via the LDL-receptor and internalized the AB/ProA–DexS complex that was bound to LDL. Therefore, this process demonstrates our attempt to navigate the etiologic factor to an alternate target pathway such as the LDL salvage.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 65 (7), 649-652, 2017
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679154767232
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- NII Article ID
- 130006772514
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 028313049
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- PubMed
- 28674338
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed