Effects of N,N-dimethyldodecylamine-N-oxide on some cellular parameters of rat thymocytes

• Fukunaga, Eri

• Ohiwa, Yurie

• Yamada, Mari

• Sumi, Ayaka

• Satoh, Masaya

• Oyama, Yasuo

抄録

N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.

収録刊行物

• Natural Science Research

  Natural Science Research 29 (1), 1-4, 2015-01

  [徳島] : 徳島大学総合科学部 ; 1988-2015

キーワード

• N,N-dimethyldodecylamine-N-oxide (DDAO)
• cytotoxicity
• lymphocyte

詳細情報

• CRID: 1050001337466245888
• NII論文ID: 110010016063
• NII書誌ID: AN10065859
• ISSN: 09146385
• NDL書誌ID: 028436027
• Web Site: http://repo.lib.tokushima-u.ac.jp/111004
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028436027
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
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  • NDL
  • CiNii Articles
  • KAKEN