細胞シートを用いた歯周組織の再生

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  • 鬼塚 理
    東京女子医科大学　先端生命医科学研究所
  • 岩田 隆紀
    東京女子医科大学　先端生命医科学研究所

書誌事項

タイトル別名
  • Translational Research of Periodontal Regeneration Using Cell Sheet Engineering
  • サイボウ シート オ モチイタ シシュウ ソシキ ノ サイセイ

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抄録

Periodontitis is a chronic inflammatory disorder that causes deterioration of the periodontal tissues that support teeth. Several biomaterials, such as bone graft materials, barrier membranes and protein products, have been developed and used clinically to repair periodontal tissue defects clinically. However, it is difficult to regenerate the complete periodontal tissue structure. Recently, regenerative therapies using multipotent mesenchymal stromal cells (MSC) have been introduced to overcome the limitation of conventional procedures. These cytotherapies have been shown to be safe and effective for the treatment of periodontal tissue defects. In order to achieve more effective treatment, our strategy has been to integrate this stem cell biology and cell sheet engineering. This cell sheet technology has already been employed in clinical trials (one of these has already approved), confirming the safety and efficacy of the treatment method. In this review, we introduce recent progress in the engineering of cell sheets and review the potential of cell sheet technology for periodontal regenerative medicine.

収録刊行物

  • 膜

    膜 43 (2), 56-62, 2018

    日本膜学会

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