胃内酸性条件における薬物の安定性に関する研究 Studies on Stability of Drugs under Acidic Conditions in the Stomach

この論文にアクセスする

この論文をさがす

著者

    • 猪爪, 信夫 イノツメ, ノブオ

書誌事項

タイトル

胃内酸性条件における薬物の安定性に関する研究

タイトル別名

Studies on Stability of Drugs under Acidic Conditions in the Stomach

著者名

猪爪, 信夫

著者別名

イノツメ, ノブオ

学位授与大学

千葉大学

取得学位

薬学博士

学位授与番号

乙第832号

学位授与年月日

1986-12-08

注記・抄録

博士論文

学位:千大院薬博乙第39号

抄録:Reversible hydrolytic reactions of various benzodiazepines and thienodiazepines in acidic solutions at body temperature were studied. The reactions of these drugs apparently took place at the azomethine bonds and the corresponding open-ring compounds produced were in equilibrium with the parent closed-ring compounds, but their reactivities were quite dependent on both chemical structures and the nature of substituents. The major factor influencing reactivity of azomethine bond cleavage in acidic solutions appears to be the electron density of 5-carbon. Similar results were obtained in nitrofurantoin and dantrolene. The experimental data obtained in the present study suggest that some benzodiazepines dissolved in the stomach are hydrolyzed to form the corresponding open-ring compounds because of the acidic environment in the stomach. When the open-ring compounds enter the intestine, they revert back to parent benzodiazepines due to the increase in pH value of the medium. The possible closure of the open-ring was confirmed by the detection of diazepam in serum after oral administration of the open-ring compound of diazepam to a human volunteer.

1アクセス

各種コード

  • NII論文ID(NAID)
    500000007883
  • NII著者ID(NRID)
    • 8000000007883
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000172197
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
ページトップへ