Decreased plasma fibronectin in liver diseases correlated to the severity of fibrotic, inflammatory and necrotic changes of liver tissue 肝疾患で減少した血漿フィブロネクチンは肝組織の線維化,炎症及び壊死の程度に相関した

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著者

    • 治徳, 通博 ジトク, ミチヒロ

書誌事項

タイトル

Decreased plasma fibronectin in liver diseases correlated to the severity of fibrotic, inflammatory and necrotic changes of liver tissue

タイトル別名

肝疾患で減少した血漿フィブロネクチンは肝組織の線維化,炎症及び壊死の程度に相関した

著者名

治徳, 通博

著者別名

ジトク, ミチヒロ

学位授与大学

岡山大学

取得学位

医学博士

学位授与番号

乙第1732号

学位授与年月日

1986-12-31

注記・抄録

博士論文

We applied a modified enzyme-linked immunosorbent assay (ELISA) for the measurement of human plasma fibronectin and determined the level of plasma fibronectin in 90 patients with various liver diseases and 10 normal subjects. Diagnoses were made by liver biopsy under peritoneoscopy. Plasma fibronectin was significantly decreased in liver cirrhosis patients, but not in acute hepatitis or chronic hepatitis patients. Decreased plasma fibronectin was correlated poorly with 18 laboratory tests, including liver function tests, and inflammatory marker determinations performed prior to peritoneoscopy. A correlation was found between the decreased plasma fibronectin and the severity of fibrotic, inflammatory and necrotic changes of the liver. These results suggested that the level of plasma fibronectin may reflect the severity of tissue injury resulting from chronic liver diseases.

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各種コード

  • NII論文ID(NAID)
    500000007942
  • NII著者ID(NRID)
    • 8000000007942
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000172256
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
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