Molecular biological studies on the paramyosin gene (unc-15) mutants and intragenic revertants in Caenorhabditis elegans 線虫Caenorhabditis elegansにおけるパラミオシン遺伝子(unc-15)突然変異体及び遺伝子内復帰突然変異体の分子生物学的研究
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Bibliographic Information
- Title
-
Molecular biological studies on the paramyosin gene (unc-15) mutants and intragenic revertants in Caenorhabditis elegans
- Other Title
-
線虫Caenorhabditis elegansにおけるパラミオシン遺伝子(unc-15)突然変異体及び遺伝子内復帰突然変異体の分子生物学的研究
- Author
-
安藤, 恵子
- Author(Another name)
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アンドウ, ケイコ
- University
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岡山大学
- Types of degree
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学術博士
- Grant ID
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甲第936号
- Degree year
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1991-03-28
Note and Description
博士論文
Table of Contents
- CONTENTS / p2 (0004.jp2)
- Abbreviations / p4 (0006.jp2)
- List of tables / p5 (0007.jp2)
- List of figures / p6 (0008.jp2)
- 1. Summary / p8 (0010.jp2)
- 2. Introduction / p11 (0013.jp2)
- 2.1 Caenorhabditis elegans as an experimental organism / p11 (0013.jp2)
- 2.2 The problems in muscle biology / p13 (0015.jp2)
- 2.3 Muscle of C. elegans / p14 (0016.jp2)
- 2.4 Paramyosin mutants / p21 (0023.jp2)
- 3. Materials and Methods / p23 (0025.jp2)
- 3.1 Worm strains and culture / p23 (0025.jp2)
- 3.2 Cloning unc-15 gene / p23 (0025.jp2)
- 3.3 DNA sequence analysis / p26 (0028.jp2)
- 3.4 Asymmetric PCR methods / p26 (0028.jp2)
- 3.5 Direct sequencing / p26 (0028.jp2)
- 3.6 Immunological procedure / p29 (0031.jp2)
- 3.7 Immunofluorescence and microscopy / p29 (0031.jp2)
- 4.Results / p30 (0032.jp2)
- 4.1 Muscle structure of unc-15 mutants / p30 (0032.jp2)
- 4.2 Molecular identification of mutations / p42 (0044.jp2)
- 4.3 Relationships between mutations and molecular models of paramyosin assembly / p59 (0061.jp2)
- 4.4 Antigenicity of mutant paramyosins / p62 (0065.jp2)
- 4.5 The weak spots of paramyosin rods / p65 (0068.jp2)
- 5. Discussion / p70 (0073.jp2)
- 5.1 Mutations in the unc-15 gene / p70 (0073.jp2)
- 5.2 Charge interaction between paramyosin rods / p73 (0076.jp2)
- 5.3 The effect of a single charge change on the assembly of helical proteins / p76 (0079.jp2)
- 5.4 The C-terminal cluster may play an important role in thick filament assembly / p77 (0080.jp2)
- 5.5 Interaction with other proteins / p78 (0081.jp2)
- 6. Conclusion / p80 (0083.jp2)
- 7. References / p81 (0084.jp2)
- Acknowledgements / p91 (0094.jp2)