犬肝切除後におけるランゲルハンス島の機能的,形態学的変化とGI療法による影響 Effect of glucagon and insulin on the histochemical and functional alternation the Langerhans islands after hepatectomy in dogs in
Effect of glucagon and insulin on the histochemical and functional alternation the Langerhans islands after hepatectomy in dogs in
[ABSTRACT] The importance of liver-pancreas relationship has been pointed out recently, and out laboratory reported hypertrophy of Langerhans islandsof dogs after partial hepatectomy. The effect of glucaon and insulin (GI therapy) on the islets in dogs was investigated to clarify the mechanism of this hypertrophy. In ac ontrol group, a forty-percent hepatectomy was carried out. One and four weeks after the surgery, 0.5g/kg of glucose was administered intravenously, and followed by a blood sampling from the portal vein to measure the changes of glucose, insulin, and glucagon, respectively. In addition, areal changes of the islets of Langerhans after the operation were measured with P AP technique. In a GI group, the same experiment as in the control group was done and 1 mg of glucagon and 2 iu/kg of insulin were administered every morning after the operation. The following results were obtained, 1) In the control group， portal plasma insulin level and insulin rlsponse were decreased one week after the surgery, and sizes of islets were enlarged four weeks after the surgery. 2) In the GI group，t here were no decrease in portal plasma insulin level and insulin response one week after the surgery, and no enlargement of the sizes of the islets four week after the surgery. 3) Changes in glucagon level and response was same as those of insulin. Glucose level and response showed no difference between the two groups. 4) According to these observations，g lucagon and insulin are exhausted one week after hepatectomy in dogs. 80 it seems to be necessary to provide gsucagon and insulin after hepatectomy.
学位の種類：医学 学位授与年月日：1991/3/15 指導：久山, 健 教授, Director : Prof. Kuyama, Takeshi ) 報告番号：甲第185号 学内授与番号：医甲143 NDL書誌ID：000000239657