Biochemical and physiological studies on cellular protein phosphorylation during epileptogenic seizure activity in central nervous system てんかん性痙攣波発現時における中枢神経系の細胞内タンパク質のリン酸化
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著者
書誌事項
- タイトル
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Biochemical and physiological studies on cellular protein phosphorylation during epileptogenic seizure activity in central nervous system
- タイトル別名
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てんかん性痙攣波発現時における中枢神経系の細胞内タンパク質のリン酸化
- 著者名
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小野塚, 実
- 著者別名
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オノズカ, ミノル
- 学位授与大学
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東京都立大学
- 取得学位
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理学博士
- 学位授与番号
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乙第754号
- 学位授与年月日
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1991-02-21
注記・抄録
博士論文
目次
- Content/p1 (4コマ目)
- I.GENERAL INTRODUCTION/p1 (7コマ目)
- A.Overview of Epilepsy/p1 (7コマ目)
- B.Previous Mechanisms for Epileptogenesis/p1 (7コマ目)
- C.Protein Phosphorylation as Molecular Approach to Epilepsy/p6 (12コマ目)
- II.SPECIFIC SYNAPTOSOMAL PROTEIN PHOSPHORYLATION DURING PENTYLENETETRAZOLE-INDUCED EPILEPTOGENIC DISCHARGES IN RAT CEREBRAL CORTEX/p11 (17コマ目)
- A.Introduction/p11 (17コマ目)
- B.Experimental/p12 (18コマ目)
- C.Results/p15 (21コマ目)
- D.Discussion/p30 (36コマ目)
- III.PROTEIN PHOSPHORYLATION-MEDIATED INTRACELLULAR CALCIUM MOVEMENT WITHIN PENTYLENETETRAZOLE-INDUCED EPILEPTOGENIC CORTEX OF RAT/p35 (41コマ目)
- A.Introduction/p35 (41コマ目)
- B.Experimental/p36 (42コマ目)
- C.Results/p39 (45コマ目)
- D.Discussion/p50 (56コマ目)
- IV.PROTEIN PHOSPHORYLATION IN MEMBRANE PROPERTIES WHICH MAY LEAD TO EPILEPTOGENIC SEIZURE ACTIVITY IN EUHADRA NEURONS/p54 (60コマ目)
- A.Introduction/p54 (60コマ目)
- B.Pentylenetetrazole-Induced Bursting Activity and Cellular Protein Phosphorylation in Euhadra Neurons/p57 (63コマ目)
- C.Involvement of Cyclic AMP-Dependent Protein Phosphorylation in Membrane Currents in Euhadra Neurons/p68 (74コマ目)
- D.Activation of Membrane Potassium Current by Caldum/Calmodulin-Dependent Protein Phosphorylation/p84 (90コマ目)
- V.GENERAL CONSIDERATION/p101 (107コマ目)
- A.Synaptosomal Protein Phosphorylation System Presumedly Associated with Epileptogenic Activity/p101 (107コマ目)
- B.Role of Protein Phosphorylation-Induced Intracellular Ca²⁺ Release in Epileptogenic Seizure Discharges/p105 (111コマ目)
- C.Protein Phosphorylation in Channel Regulation Presumably Linked with Epileptogenic Discharge/p106 (112コマ目)
- VI.CONCLUSION/p112 (118コマ目)
- ACKOWLEDGEMENTS/p116 (122コマ目)
- REFERENCES/p117 (123コマ目)