Synthesis and neuroexcitatory action of conformationally constrained glutamate analogues 立体配座を固定したグルタミン酸類縁体の合成と神経興奮活性
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著者
書誌事項
- タイトル
-
Synthesis and neuroexcitatory action of conformationally constrained glutamate analogues
- タイトル別名
-
立体配座を固定したグルタミン酸類縁体の合成と神経興奮活性
- 著者名
-
島本, 啓子
- 著者別名
-
シマモト, ケイコ
- 学位授与大学
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大阪大学
- 取得学位
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理学博士
- 学位授与番号
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乙第5513号
- 学位授与年月日
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1991-10-05
注記・抄録
博士論文
目次
- Contents / (0003.jp2)
- Introduction. / p1 (0005.jp2)
- Chapter1. Efficient Synthesis of All Diastereomers of 2-(Carboxycyclopropyl)glycine / p6 (0008.jp2)
- [1] Syntheses of CCG-I～IV(1-4). / p7 (0008.jp2)
- Chapter2. Stereoselective Approaches to the Synthesis or CCGs. / p22 (0016.jp2)
- [1] Syntheses of CCG-I (1) and II (2). Palladium Catalyzed Cycloaddition of Diazomethane to (E)-Olefins. / p22 (0016.jp2)
- [2] Syntheses of CCG-III (3) and IV (4) via Intramolecular Cyclopropanation. / p29 (0019.jp2)
- [3] Stereoselective Synthesis of CCG-III (3) and IV (4). / p33 (0021.jp2)
- Chapter3. Syntheses of 3'-Substituted Analogues of L-CCG-III and IV. / p42 (0026.jp2)
- [1] Syntheses of Diazoacetoamide with(E)-or(Z)- Allylalcohol. / p44 (0027.jp2)
- [2] Syntheses of Trans Substituted Isomers,t-MCG-III-(24) and t-MCG-IV(26). / p46 (0028.jp2)
- [3] Syntheses of Cis Substituented Isomers,c-MCG-III(25) and c-MCG-IV(27). / p49 (0029.jp2)
- Chapter4. Neuobiological Activities of CCGs and Their Derivatives. The Structure-Activity Relationships. / p54 (0032.jp2)
- [1] Neurobiological Activities of CCGs(1～4) and the Conformation-Activity Relationships. / p57 (0033.jp2)
- [2] Effect of the Cyclopropyl Ring. / p64 (0037.jp2)
- [3] Biological Activities of the 3'-Substituted Derivatives of CCG-III and IV(24～27). / p65 (0037.jp2)
- Conclusion / p73 (0041.jp2)
- Experimental Section / p76 (0043.jp2)
- Chapter1 / p77 (0043.jp2)
- Chapter2 / p85 (0047.jp2)
- Chapter3 / p98 (0054.jp2)
- Chapter4 / p121 (0065.jp2)
- References / p122 (0066.jp2)
- Publication list / p128 (0069.jp2)
- Abbreviations / p130 (0070.jp2)
- Acknowledgment / p132 (0071.jp2)