Studis on antifungal antibiotics tautomycin and tautomycetin 新規抗真菌抗生物質トウトマイシン及びトウトマイセチンに関する研究

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著者

    • 成, 杏春 チョン, シンチュン

書誌事項

タイトル

Studis on antifungal antibiotics tautomycin and tautomycetin

タイトル別名

新規抗真菌抗生物質トウトマイシン及びトウトマイセチンに関する研究

著者名

成, 杏春

著者別名

チョン, シンチュン

学位授与大学

東京大学

取得学位

農学博士

学位授与番号

乙第9855号

学位授与年月日

1990-10-08

注記・抄録

博士論文

目次

  1. 論文の内容の要旨 / p1 (0001.jp2)
  2. CONTENTS / p5 (0010.jp2)
  3. PREFACE / p2 (0007.jp2)
  4. PART I.Biology and Chemistry of Tautomycin(TM) / p8 (0013.jp2)
  5. Chapter1.TM-producing microorganism / p8 (0013.jp2)
  6. Chapter2.Isolation and physico-chemical properties of TM / p11 (0016.jp2)
  7. Chapter3.Biological activity of TM / p22 (0027.jp2)
  8. 3-1.MIC of TM / p22 (0027.jp2)
  9. 3-2.Activities against Sclerotinia sclerotiolum and cucumber gray mold / p23 (0028.jp2)
  10. 3-3.Induction of morphological change of human myeloid leukemia / p26 (0031.jp2)
  11. 3-4.Toxicity / p27 (0032.jp2)
  12. Chapter4.Structural elucidation of TM / p28 (0033.jp2)
  13. 4-1.Partial structure of TM / p28 (0033.jp2)
  14. 4-2.General approach for structure elucidation of TM / p37 (0042.jp2)
  15. 4-3.Hydrolysis of TM at pH 9 / p40 (0045.jp2)
  16. 4-4.Acetylation of TM-2 / p45 (0050.jp2)
  17. 4-5.Retrol-aldol cleavage of TM-2 / p50 (0055.jp2)
  18. 4-6.Ozonolysis of TM-2a / p67 (0072.jp2)
  19. 4-7.Monomethyl ester and trimethyl esters of TM-3 / p72 (0077.jp2)
  20. 4-8.2,3-Dialkylmaleic anhydride moiety and equilibrium / p87 (0092.jp2)
  21. 4-9.Total NMR assignment of TM / p92 (0097.jp2)
  22. PART II.Biology and Chemistry of Tautomycetin(TMT) / (0099.jp2)
  23. Chapterl.TMT-producing microorganism / p94 (0100.jp2)
  24. Chapter2.Isolation and physico-chemical properties of TMT / p97 (0103.jp2)
  25. Chapter3.Biological activity of TMT / p109 (0115.jp2)
  26. 3-1.MIC of TMT / p109 (0115.jp2)
  27. 3-2.Activities against Sclerotinia sclerotiolum and cucumber gray mold / p110 (0116.jp2)
  28. 3-3.Induction of morphological change of human myeloid leukemia / p111 (0117.jp2)
  29. 3-4.Toxicity / p111 (0117.jp2)
  30. Chapter4.structural elucidation of TMT / p112 (0118.jp2)
  31. 4-1.Degradation of TMT / p112 (0118.jp2)
  32. 4-2.Hydrolysis of TMT / p113 (0119.jp2)
  33. 4-3.Acetylation of TMT-2 / p118 (0124.jp2)
  34. 4-4.Monomethyl ester and trimethyl ester of TMT-3 / p131 (0137.jp2)
  35. 4-5.Total NMR assignment of TMT / p136 (0142.jp2)
  36. PART III.Biosynthesis of TM and TMT / p138 (0144.jp2)
  37. Chapter1.Biosynthesis of TM / p138 (0144.jp2)
  38. Chapter2.Biosynthesis of TMT / p157 (0163.jp2)
  39. PART IV.stereochemistry of TM / p173 (0179.jp2)
  40. Chapter1.Absolute configuration of C-3'at TM / p174 (0180.jp2)
  41. Chapter2.Relative configurations of spiroketal moiety of TM / p177 (0183.jp2)
  42. Chapter3.Relative configuration of C-22,C-23 and C-24 of TM / p184 (0190.jp2)
  43. PART V.Discussion / p190 (0196.jp2)
  44. PART VI.Experimental / p195 (0201.jp2)
  45. Chapter1.General procedure / p195 (0201.jp2)
  46. Chapter2.Preparation of TM and related degradation compounds / p197 (0203.jp2)
  47. Chapter3.Preparation of TMT and related degradation compounds / p207 (0213.jp2)
  48. Chapter4.Preparation of 〔¹³C〕and〔¹⁴C〕labeled TM and TMT / p212 (0218.jp2)
  49. Chapter5.Preparation of derivatives of TM for stereochemical studies / p215 (0221.jp2)
  50. SUMMARY / p217 (0223.jp2)
  51. REFERENCES / p218 (0224.jp2)
  52. ACKNOWLEDGMENTS / p223 (0229.jp2)
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各種コード

  • NII論文ID(NAID)
    500000083182
  • NII著者ID(NRID)
    • 8000000083392
  • DOI(NDL)
  • NDL書誌ID
    • 000000247496
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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