Physiological pharmacokinetics of biologically active peptides : roles of receptor binding and endocytosis on the pharmacokinetics of opioid peptides and insulin 生理活性ペプタイドの生理学的薬物速度論 : オピオイド及びインスリンの体内動態におけるレセプター結合・エンドサイトーシスの役割

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著者

    • 佐藤, 均, 1959- サトウ, ヒトシ

書誌事項

タイトル

Physiological pharmacokinetics of biologically active peptides : roles of receptor binding and endocytosis on the pharmacokinetics of opioid peptides and insulin

タイトル別名

生理活性ペプタイドの生理学的薬物速度論 : オピオイド及びインスリンの体内動態におけるレセプター結合・エンドサイトーシスの役割

著者名

佐藤, 均, 1959-

著者別名

サトウ, ヒトシ

学位授与大学

東京大学

取得学位

薬学博士

学位授与番号

乙第10082号

学位授与年月日

1991-03-08

注記・抄録

博士論文

目次

  1. TABLE OF CONTENTS / p2 (0004.jp2)
  2. ACKNOWLEDGEMENTS / p1 (0003.jp2)
  3. CONTENTS / p2 (0004.jp2)
  4. GENERAL INTRODUCTION / p1 (0006.jp2)
  5. PART I:Physiologically-based Pharmacokinetics of Radioiodinated Human β-Endorphin in Rats:An Application of the Capillary Membrane-Limited Model. / p3 (0007.jp2)
  6. A.Summary / p4 (0008.jp2)
  7. B.Introduction / p5 (0008.jp2)
  8. C.Materials and Methods / p7 (0009.jp2)
  9. D.Results / p14 (0013.jp2)
  10. E.Discussion / p19 (0015.jp2)
  11. F.References / p26 (0019.jp2)
  12. G.Appendix / p31 (0021.jp2)
  13. H.Tables and Figures / p39 (0025.jp2)
  14. PARTII:In Vivo Evidence for the Specific Binding of Human β-Endorphin to the Lung and Liver of the Rat. / p52 (0033.jp2)
  15. A.Summary / p53 (0033.jp2)
  16. B.Introduction / p54 (0034.jp2)
  17. C.Materials and Methods / p55 (0034.jp2)
  18. D.Results / p59 (0036.jp2)
  19. E.Discussion / p61 (0037.jp2)
  20. F.References / p65 (0039.jp2)
  21. G.Tables and Figures / p68 (0041.jp2)
  22. PARTIII:Specific Binding and Clearance of 3H-Dynorphin(1-13)in the Perfused Rat Lung:An Application of the Multiple-Indicator Dilution Method. / p73 (0044.jp2)
  23. A.Summary / p74 (0045.jp2)
  24. B.Introduction / p75 (0045.jp2)
  25. C.Materials and Methods / p76 (0046.jp2)
  26. D.Results and Discussion / p80 (0048.jp2)
  27. E.References / p85 (0050.jp2)
  28. F.Tables and Figures / p88 (0052.jp2)
  29. PARTIV:Specific Binding of β-Endorphin to the Isolated Renal Basolateral Membranes In Vitro. / p92 (0055.jp2)
  30. A.Summary / p93 (0055.jp2)
  31. B.Introduction / p94 (0056.jp2)
  32. C.Materials and Methods / p95 (0056.jp2)
  33. D.Results and Discussion / p99 (0058.jp2)
  34. E.References / p106 (0062.jp2)
  35. F.Tables and Figures / p111 (0064.jp2)
  36. PARTV:Absorptive-Mediated Endocytosis of a Dynorphin-like Analgesic Peptide, E-2078, into the Blood-Brain Barrier. / p120 (0070.jp2)
  37. A.Summary / p121 (0070.jp2)
  38. B.Introduction / p122 (0071.jp2)
  39. C.Materials and Methods / p124 (0072.jp2)
  40. D.Results / p130 (0075.jp2)
  41. E.Discussion / p134 (0077.jp2)
  42. F.References / p139 (0079.jp2)
  43. G.Tables and Figures / p143 (0081.jp2)
  44. PARTVI:Application of HPLC in Disposition Study of A14-¹²⁵I-Labeled Insulin in Mice. / p156 (0089.jp2)
  45. A.Summary / p157 (0089.jp2)
  46. B.Introduction / p159 (0090.jp2)
  47. C.Materials and Methods / p161 (0091.jp2)
  48. D.Results / p166 (0094.jp2)
  49. E.Discussion / p169 (0095.jp2)
  50. F.References / p176 (0099.jp2)
  51. G.Tables and Figures / p180 (0101.jp2)
  52. PARTVII:Effect of Receptor Up-Regulation on Insulin Pharmacokinetics in Streptozotocin-Treated Diabetic Rats. / p185 (0104.jp2)
  53. A.Summary / p186 (0105.jp2)
  54. B.Introduction / p187 (0105.jp2)
  55. C.Materials and Methods / p189 (0106.jp2)
  56. D.Results / p196 (0110.jp2)
  57. E.Discussion / p198 (0111.jp2)
  58. F.Appendix / p202 (0113.jp2)
  59. G.References / p204 (0114.jp2)
  60. H.Tables and Figeres / p209 (0116.jp2)
  61. PARTVIII:Receptor-Mediated Endocytosis of A₁₄₋¹²⁵I-Insulin by the Nonfiltering Perfused Rat Kidney. / p215 (0120.jp2)
  62. A.Summary / p216 (0121.jp2)
  63. B.Introduction / p217 (0121.jp2)
  64. C.Materials and Methods / p219 (0122.jp2)
  65. D.Results / p225 (0125.jp2)
  66. E.Discussion / p229 (0127.jp2)
  67. F.Appendix / p236 (0131.jp2)
  68. G.References / p238 (0132.jp2)
  69. H.Tables and Figures / p243 (0134.jp2)
  70. PARTIX:Receptor-Recycling Model of Clearance and Distribution of Insulin in the Perfused Mouse Liver. / p251 (0139.jp2)
  71. A.Summary / p252 (0140.jp2)
  72. B.Introduction / p254 (0141.jp2)
  73. C.Materials and Methods / p256 (0142.jp2)
  74. D.Results / p265 (0146.jp2)
  75. E.Discussion / p269 (0148.jp2)
  76. F.References / p273 (0150.jp2)
  77. G.Tables and Figures / p278 (0153.jp2)
  78. PARTX:Physiological Modeling of Receptor-Mediated Distribution and Clearance of Insulin in Mice. / p291 (0160.jp2)
  79. A.Summary / p292 (0161.jp2)
  80. B.Introduction / p293 (0161.jp2)
  81. C.Materials and Methods / p295 (0162.jp2)
  82. D.Results / p302 (0166.jp2)
  83. E.Discussion / p304 (0167.jp2)
  84. F.Appendix / p309 (0169.jp2)
  85. G.References / p316 (0173.jp2)
  86. H.Tables and Figures / p322 (0176.jp2)
  87. CONCLUSIONS AND PERSPECTIVES / p334 (0182.jp2)
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  • NII論文ID(NAID)
    500000083409
  • NII著者ID(NRID)
    • 8000001012468
  • DOI(NDL)
  • NDL書誌ID
    • 000000247723
  • データ提供元
    • NDL ONLINE
    • NDLデジタルコレクション

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