ジヒドロピリジン誘導体による多剤耐性の克服 ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク Overcoming drug resistance in cancer cells with dihydropyridine analogues

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著者

    • 神渡, 幹夫 カンド, ミキオ

書誌事項

タイトル

ジヒドロピリジン誘導体による多剤耐性の克服

タイトル別名

ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク

タイトル別名

Overcoming drug resistance in cancer cells with dihydropyridine analogues

著者名

神渡, 幹夫

著者別名

カンド, ミキオ

学位授与大学

鹿児島大学

取得学位

医学博士

学位授与番号

乙第861号

学位授与年月日

1990-04-25

注記・抄録

博士論文

Ten synthetic dihydropyridine analogues were investigated for their ability to reverse drug-resistance in a multidrug-resistant human carcinoma cell line, KB-Cl. Four dihydropyridine analogues completely reversed the resistance, 3 lowered the resistance and 3 had little effect. The radioactive photoactive dihydropyridine calcium channel blocker, [^3H] azidopine, photolabels P-glycoprotein in membrane vesicles from KB-Cl cells. This photolabeling was almost completely inhibited by excess dihydropyridine analogues that reversed or lowered drug-resistance. In contrast, the labeling was not significantly inhibited by analogues that do not reverse resistance. Among other reversing agents, cepharanthine and reserpine inhibited the [^3H] azidopine photolabeling, but thioridazine did not. SDB-ethylenediamine slightly inhibited the labeling at 100μM. An anticancer agent, vinblastine also inhibited the labeling. The correlation between the reversing of the drug-resistance and the inhibition of the [^3H] azidopin photolabeling of P-glycoprotein by dihydropyridine analogues suggests a role for P-glycoprotein in multidrug-resist ance and also the reversing of the resistance by dihydropyridine analogues.

医歯学総合研究科博士論文(医学) ; 学位取得日: 平成2年4月25日

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各種コード

  • NII論文ID(NAID)
    500000083742
  • NII著者ID(NRID)
    • 8000000083952
  • DOI(NDL)
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000248056
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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