ジヒドロピリジン誘導体による多剤耐性の克服 Overcoming drug resistance in cancer cells with dihydropyridine analogues ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク

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Author

    • 神渡, 幹夫 カンド, ミキオ

Bibliographic Information

Title

ジヒドロピリジン誘導体による多剤耐性の克服

Other Title

Overcoming drug resistance in cancer cells with dihydropyridine analogues

Other Title

ジヒドロピリジン ユウドウタイ ニヨル タザイ タイセイ ノ コクフク

Author

神渡, 幹夫

Author(Another name)

カンド, ミキオ

University

鹿児島大学

Types of degree

医学博士

Grant ID

乙第861号

Degree year

1990-04-25

Note and Description

博士論文

Ten synthetic dihydropyridine analogues were investigated for their ability to reverse drug-resistance in a multidrug-resistant human carcinoma cell line, KB-Cl. Four dihydropyridine analogues completely reversed the resistance, 3 lowered the resistance and 3 had little effect. The radioactive photoactive dihydropyridine calcium channel blocker, [^3H] azidopine, photolabels P-glycoprotein in membrane vesicles from KB-Cl cells. This photolabeling was almost completely inhibited by excess dihydropyridine analogues that reversed or lowered drug-resistance. In contrast, the labeling was not significantly inhibited by analogues that do not reverse resistance. Among other reversing agents, cepharanthine and reserpine inhibited the [^3H] azidopine photolabeling, but thioridazine did not. SDB-ethylenediamine slightly inhibited the labeling at 100μM. An anticancer agent, vinblastine also inhibited the labeling. The correlation between the reversing of the drug-resistance and the inhibition of the [^3H] azidopin photolabeling of P-glycoprotein by dihydropyridine analogues suggests a role for P-glycoprotein in multidrug-resist ance and also the reversing of the resistance by dihydropyridine analogues.

医歯学総合研究科博士論文(医学) ; 学位取得日: 平成2年4月25日

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Codes

  • NII Article ID (NAID)
    500000083742
  • NII Author ID (NRID)
    • 8000000083952
  • DOI(NDL)
  • Text Lang
    • jpn
  • NDLBibID
    • 000000248056
  • Source
    • Institutional Repository
    • NDL ONLINE
    • NDL Digital Collections
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