Three-dimensional structure of a highly thermostable enzyme, 3-isopropylmalate dehydrogenase 耐熱性タンパク質3-イソプロピルリンゴ酸脱水素酵素の立体構造

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著者

    • 今田, 勝巳 イマダ, カツミ

書誌事項

タイトル

Three-dimensional structure of a highly thermostable enzyme, 3-isopropylmalate dehydrogenase

タイトル別名

耐熱性タンパク質3-イソプロピルリンゴ酸脱水素酵素の立体構造

著者名

今田, 勝巳

著者別名

イマダ, カツミ

学位授与大学

大阪大学

取得学位

理学博士

学位授与番号

甲第4442号

学位授与年月日

1992-03-25

注記・抄録

博士論文

10135

博士(理学)

1992-03-25

大阪大学

14401甲第04442号

目次

  1. Contents / p3 (0005.jp2)
  2. Chapter-1 / p1 (0006.jp2)
  3. General Introduction / p1 (0006.jp2)
  4. Chapter-2 / p7 (0009.jp2)
  5. Structure Determination of Tt-IPMDH / p7 (0009.jp2)
  6. 2-1 Crystallization / p7 (0009.jp2)
  7. 2-2 Crystallographic parameters / p10 (0011.jp2)
  8. 2-3 Heavy-atom derivatives / p10 (0011.jp2)
  9. 2-4 Data collection / p16 (0014.jp2)
  10. 2-5 Phase determination / p21 (0016.jp2)
  11. 2-6 Model building and refinement / p26 (0019.jp2)
  12. Chapter-3 / p36 (0024.jp2)
  13. Structure of Tt-IPMDH / p36 (0024.jp2)
  14. 3-1 Subunit structure / p36 (0024.jp2)
  15. 3-2 First domain / p42 (0027.jp2)
  16. 3-3 Second domain / p43 (0027.jp2)
  17. 3-4 Arm region / p44 (0028.jp2)
  18. 3-5 Solvent structure / p46 (0029.jp2)
  19. 3-6 Main chain hydrogen bonds / p49 (0030.jp2)
  20. 3-7 Heavy-atom binding sites / p49 (0030.jp2)
  21. 3-8 Lattice contacts / p57 (0034.jp2)
  22. 3-9 Quartemary structure / p57 (0034.jp2)
  23. Chapter-4 / p67 (0039.jp2)
  24. Comparison with Other Dehydrogenases / p67 (0039.jp2)
  25. 4-1 Well known dehydrogenases / p67 (0039.jp2)
  26. 4-2 ICDH from E.coli. / p68 (0040.jp2)
  27. 4-3 IPMDHs from other organisms / p70 (0041.jp2)
  28. 4-4 T.aquaticus IPMDH / p73 (0042.jp2)
  29. Chapter-5 / p75 (0043.jp2)
  30. Active Site / p75 (0043.jp2)
  31. 5-1 Substrate binding site / p75 (0043.jp2)
  32. 5-2 Possible NAD binding site / p78 (0045.jp2)
  33. Chapter-6 / p80 (0046.jp2)
  34. The Structure of Tt-IPMDH Obtained from Highly Concentrated (NH₄)₂SO₄ Solution / p80 (0046.jp2)
  35. 6-1 Data collection and reduction / p80 (0046.jp2)
  36. 6-2 Structure description and comparison with Tt-IPMDH / p81 (0046.jp2)
  37. Chapter-7 / p87 (0049.jp2)
  38. Structure of Chimeric IPMDH / p87 (0049.jp2)
  39. 7-1 Crystallization / p91 (0051.jp2)
  40. 7-2 Data collection / p91 (0051.jp2)
  41. 7-3 Model building and refinement / p95 (0053.jp2)
  42. 7-4 Structure description and comparison with Tt-IPMDH / p98 (0055.jp2)
  43. Chapter-8 / p113 (0062.jp2)
  44. Thermostability / p113 (0062.jp2)
  45. 8-1 Disulfide bond / p115 (0063.jp2)
  46. 8-2 Shorter loop / p115 (0063.jp2)
  47. 8-3 Proline residue / p117 (0064.jp2)
  48. 8-4 Hydrogen bonds and electrostatic interaction / p117 (0064.jp2)
  49. 8-5 Hydrophobic interaction / p118 (0065.jp2)
  50. Chapter-9 / p128 (0070.jp2)
  51. Structure and B-factor Analysis / p128 (0070.jp2)
  52. 9-1 Temperature control / p130 (0071.jp2)
  53. 9-2 Data collection / p130 (0071.jp2)
  54. 9-3 Data processing / p134 (0073.jp2)
  55. 9-4 Refinement / p136 (0074.jp2)
  56. 9-5 Structure description in various temperatures / p139 (0075.jp2)
  57. 9-6 B-factor / p139 (0075.jp2)
  58. Chapter-10 / p148 (0080.jp2)
  59. Summary and Conclusion / p148 (0080.jp2)
  60. References / p153 (0082.jp2)
  61. List of Publications / p159 (0085.jp2)
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各種コード

  • NII論文ID(NAID)
    500000084264
  • NII著者ID(NRID)
    • 8000000084475
  • DOI(NDL)
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000000248578
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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