The conformation-activity relationships of α-human atrial natriuretic peptide (α-hANP) ヒト心房性ナトリウム利尿ペプチド(α-hANP)の立体構造と活性の相関
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著者
書誌事項
- タイトル
-
The conformation-activity relationships of α-human atrial natriuretic peptide (α-hANP)
- タイトル別名
-
ヒト心房性ナトリウム利尿ペプチド(α-hANP)の立体構造と活性の相関
- 著者名
-
小山, 智士
- 著者別名
-
コヤマ, サトシ
- 学位授与大学
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大阪大学
- 取得学位
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理学博士
- 学位授与番号
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乙第5684号
- 学位授与年月日
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1992-03-18
注記・抄録
博士論文
目次
- CONTENTS / (0003.jp2)
- CHAPTER I General introduction / p1 (0005.jp2)
- 1-1 Back ground of this thesis / p2 (0006.jp2)
- 1-2 References / p9 (0013.jp2)
- CHAPTER II The conformation of α-human natriureticpolypeptide in solution / p12 (0016.jp2)
- 2-1 Abbreviations / p13 (0017.jp2)
- 2-2 Summary / p14 (0018.jp2)
- 2-3 Introduction / p15 (0019.jp2)
- 2-4 Materials and methods / p17 (0021.jp2)
- 2-5 Results and discussion / p18 (0022.jp2)
- 2-6 References / p28 (0032.jp2)
- CHAPTER III The differences in conformation between α-human atrial natriuretic polypeptide(α-hANP) and its derivative(Met(O)-α-hANP) in solution / p30 (0034.jp2)
- 3-1 Summary / p31 (0035.jp2)
- 3-2 Introduction / p32 (0036.jp2)
- 3-3 Materials and methods / p34 (0038.jp2)
- 3-4 Results and discussion / p38 (0042.jp2)
- 3-5 References / p64 (0068.jp2)
- CHAPTER IV An oxidized analog of α-human atrial natriuretic polypeptide(α-hANP) is a selective agonist for ANP clearance receptor(ANP-R₂ receptor) which lacks a guanylate cyclase / p66 (0070.jp2)
- 4-1 Abbreviations / p67 (0071.jp2)
- 4-2 Summary / p68 (0072.jp2)
- 4-3 Introduction / p70 (0074.jp2)
- 4-4 Materials and methods / p73 (0077.jp2)
- 4-5 Results / p78 (0082.jp2)
- 4-6 Discussion / p95 (0099.jp2)
- 4-7 References / p101 (0105.jp2)
- CHAPTER V The folded back conformation of Gln(18)Tyr(28) region in α-human atrial natriuretic polypeptide(α-hANP) is essential for signal transduction on ANP-A receptor / p104 (0108.jp2)
- 5-1 Summary / p105 (0109.jp2)
- 5-2 Introduction / p107 (0111.jp2)
- 5-3 Materials and methods / p110 (0114.jp2)
- 5-4 Results / p112 (0116.jp2)
- 5-5 Discussion / p124 (0128.jp2)
- 5-6 References / p130 (0134.jp2)
- CHAPTER VI Conclusion / p133 (0137.jp2)
- Acknowledgements / p139 (0143.jp2)
- List of publications / p140 (0144.jp2)
